Based on Marvel's fictional government organization, S.H.I.E.L.D. It shows that not all heroes have to be super.
Agent Phil Coulson (The Avengers) recruits a new team to go into the field and handle any cases involving the strange and the bizarre. Accompanying him are solo field agent Grant Ward, field agent turned desk jockey Melinda May, and British scientists Leo Fitz and Gemma Simmons. Coulson soon recruits a civilian computer hacker known only as Skye, a mystery woman with an unknown past.